No, never sold one that changed my life. But sold many that made my ex-wife happy. Everytime I was announcing to her a good sale she remembered that saw something very nice in some boutique, lol...
You will not be able to simply change your life in this field unless you are very lucky. I do not rely on it as income i have other methods, and it is certain that your life can be changed.
The domain that changed my life was my first sale (just junk I never understood why someone paid low XXX for it). From that day I'm seriously committed to make a living only selling domains. It doesn't changed my life financially but changed my approach to domaining. Now there isn't a day I don't try to study and understand how this market behaves.