No, never sold one that changed my life. But sold many that made my ex-wife happy. Everytime I was announcing to her a good sale she remembered that saw something very nice in some boutique, lol...
The domain that changed my life was my first sale (just junk I never understood why someone paid low XXX for it). From that day I'm seriously committed to make a living only selling domains. It doesn't changed my life financially but changed my approach to domaining. Now there isn't a day I don't try to study and understand how this market behaves.
You will not be able to simply change your life in this field unless you are very lucky. I do not rely on it as income i have other methods, and it is certain that your life can be changed.