Actually we purge your domains at least once every 5 days, in many cases more often than that. So our system re-optimizes, adds additional "learned" keywords and if new images have been added they are then updated.
To me the most important time to ask for help is when something doesn't look good. Somebody asked me today for a Segway template, then I looked and noticed our system didn't even fully understand what a Segway was, so with about 5 minutes of work and a template request which should be done tomorrow we have a perfect category if anybody has a domain about Segways. Did I mention that we own 6 Segways?
So if you look at one of your domains and you don't feel that the keywords really match the domain, definitely let your account manager know. Another good one is when you have a domain that on average is getting less than 20% CTR, now the domain has to have a few hundred hits overall, but sometimes we can help with those as well.
The last thing to consider is the size. If you have an account with 10 domains in it and you get 10 hits a day, it's hard for us to really make you millionaires. But 10 domains with a decent amount of hits, and you could easily see a big difference based on some changes. If you have thousands of domains, don't expect a miracle over night, but it's doable.
If you ever see that we have split your domain incorrectly, please just fix it. Our system learns when somebody fixes something like that. We had one of our customers add in 25,000 domains yesterday, and we split all of them but 19 correct. But all of his domains were spelled correctly.
Hope this helps.
Donny