Professionally, I use the initials of my first and middle name, combined and my last name.
So, say my name is John Steven Harris, I go by JS Harris in most professional contexts. I own that .com (my name isn't JS Harris, obviously :p ). This is usually a pretty reliable strategy for most people to secure a relevant yourname.com if your pure firstandlastname.com is already taken, without having to define yourself by setting up shop on an esoteric extension. If domain names are real estate and yourname.tld is your personal residence, anything other than a .com/.net/.org is living in the ghetto, as far as I see it (for US residents, anyway).
Unfortunately, my given first and last name combines to form the name of a corporation, who owns the dot-everything of it.