No, no trouble. Except if you use it for dubstep music (Skrillex) , or as an online payment service (Skrill) , then you would be fine imo.
I wanted to say that , the more a domain name looks like another well established brand , the less it's value is going to be (most of the cases at least). Check if you are getting any typo traffic off of Skrillx.com . other than that , I donnot see any other premium value for the domain. But that's just me.