Do you rather prefer Tables or Divs? I prefer tables because they can be simplier to layout a navigation system with a good content area. And tables are compatible by MSIE, Firefox, and Netscape (I think). So your site will be cross-browser compatiable :D.
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Mine and rather general recommendation is tables for tabular data, layers for general layout containers, lists for non-tabular lists of data. I cannot say I follow it at all times, but I do my best to think what is suitable.