As property appreciation rates determine profit margins... you would have to sell a $500 aftermarket name for $25,000 just to match the 50X rate of a $10 hand reg selling for $500. And $500 aftermarket domains rarely sell for $25K... so while its easy to say aftermarket names are more profitable than hand regs, I don't see anything supporting that claim.
I deal almost exclusively in hand regs, and my worst sale was a $50 .tv hand reg sold for $4K (it was my 1st sale about ten years ago)
Also, as I focus is on hot niche 'beach front' hand regs I'm aiming beyond the $100K mark, as I passed on an offer in that neighborhood earlier this year, for my DroneTV.com hand reg.