Smtp with own domain

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WhiteLion

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I was just wondering does anyone know if the smtp has to always be set to that of your isp in ones desktop email program.. Can it ever be mail.mydomain.com
pop3 is mail.mydomain.com but smtp is not, as it just does not work. Does that mean I just can't use a program like outlook if i am on a wireless network and don't know the current smtp for that isp?
Would appreciate any help on this matter
kind regards
 
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