Well, it's mainly the heading font I didn't like, the "tip of the week", "updates" etc. I think a more simple font would be nice; even arial is nice when not capitalised.
If you did change the font, I would recommend making the body text slightly smaller. Verdana BOLD is sometimes nice.
And as far as colour goes, I think something very light like #E3E3E3 would go nicely, perhaps you could use the orange to border it or something.
I think the main point is, while orange is nice, a lot of people find it oppressive and when they're trying to read it helps if the colours are more neutral.
HTH,
S.