I reckon that in the long term, these will all grow in value and usage:
.me for brands where it makes sense (love.me, choose.me, eat.me etc), and personal sites
.biz for businesses that use their own brand
.info for sites that provide info (Wikipedia-esque, recipes, facts and figures etc)
.us for American sites that wish to point out that they are actually based in the USA
Each might take a handful of well-known instances to get the ball rolling.