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Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medicationused to prevent and treat HIV/AIDS.[2] It reduces the replication of the virus and leading to clinical and immunologic improvements.[3] It can also be used to prevent HIV transmission, such as from mother to child during the period of birth or after a needle stick injury. Used by itself in HIV-infected patients, AZT slows HIV replication in patients, but does not stop it entirely.[4] HIV may become AZT-resistant over time, and therefore AZT is now usually used in conjunction with other anti-HIV drugs in the combination therapy called highly active antiretroviral therapy (HAART).
It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. AZT inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming.
AZT was the first U.S. government-approved treatment for HIV, marketed under the brand name Retrovir. AZT is included in Combivir and Trizivir. It is included in the World Health Organization's Model List of Essential Medicines, which suggests the minimum medicinal needs for a basic health care system.[5] As of 2015 the cost for a typical month of medication in the United States more than 200 USD.[6]
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Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medicationused to prevent and treat HIV/AIDS.[2] It reduces the replication of the virus and leading to clinical and immunologic improvements.[3] It can also be used to prevent HIV transmission, such as from mother to child during the period of birth or after a needle stick injury. Used by itself in HIV-infected patients, AZT slows HIV replication in patients, but does not stop it entirely.[4] HIV may become AZT-resistant over time, and therefore AZT is now usually used in conjunction with other anti-HIV drugs in the combination therapy called highly active antiretroviral therapy (HAART).
It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. AZT inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming.
AZT was the first U.S. government-approved treatment for HIV, marketed under the brand name Retrovir. AZT is included in Combivir and Trizivir. It is included in the World Health Organization's Model List of Essential Medicines, which suggests the minimum medicinal needs for a basic health care system.[5] As of 2015 the cost for a typical month of medication in the United States more than 200 USD.[6]
