michaeldotcom, yes..... absolutely. I have many of them and I use them to separate profitable domains from unprofitable domains, and for other various categorizations.
I prefer separate accounts since they are stand-alone entities. I did this so that if anyone ever got my login details they would only be able to empty one account of domains not all of them. I therefore split my profitable domains up into several accounts and unprofitable in fewer accounts. You obviously may have other reasons to want to do it but this is why I did it.
There is one drawback though - going from account to account to make changes or pay for domains.
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